EP1-antagonist-1
EP1-antagonist-1 (Compound 27) is an EP1 antagonist with a pKi (FLIPR) of 9.31 and a pIC50 (binding) of 9.88. EP1-antagonist-1 can be used for the study of PGE2-mediated pain[1].
Product Specifications
CAS Number
851204-35-8
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/1-[[5-Bromo-2-[[_2,4-dichlorophenyl_methyl]oxy]phenyl]methyl]-5-methyl-1H-pyrazole-3-carboxylic_acid.html
Purity
98.60
Smiles
O=C(C1=NN(CC2=CC(Br)=CC=C2OCC3=CC=C(Cl)C=C3Cl)C(C)=C1)O
Molecular Formula
C19H15BrCl2N2O3
Molecular Weight
470.14
References & Citations
[1]McKeown SC, et al. Identification of novel pyrazole acid antagonists for the EP1 receptor. Bioorg Med Chem Lett. 2006 Sep 15;16 (18) :4767-71. Epub 2006 Jul 14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP
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