EP1-antagonist-1

EP1-antagonist-1 (Compound 27) is an EP1 antagonist with a pKi (FLIPR) of 9.31 and a pIC50 (binding) of 9.88. EP1-antagonist-1 can be used for the study of PGE2-mediated pain[1].

Product Specifications

CAS Number

[851204-35-8]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-[[5-Bromo-2-[[_2,4-dichlorophenyl_methyl]oxy]phenyl]methyl]-5-methyl-1H-pyrazole-3-carboxylic_acid.html

Purity

98.60

Smiles

O=C(C1=NN(CC2=CC(Br)=CC=C2OCC3=CC=C(Cl)C=C3Cl)C(C)=C1)O

Molecular Formula

C19H15BrCl2N2O3

Molecular Weight

470.14

References & Citations

[1]McKeown SC, et al. Identification of novel pyrazole acid antagonists for the EP1 receptor. Bioorg Med Chem Lett. 2006 Sep 15;16 (18) :4767-71. Epub 2006 Jul 14.