Soyasaponin Ab

Soyasaponin Ab is an orally active soyasaponin. Soyasaponin Ab inhibits PPARγ transcriptional activity. Soyasaponin Ab induces apoptosis in high concentrations. Soyasaponin Ab exerts anti-obesity, anti-oxidation, anti-inflammation, anti-aging effects. Soyasaponin Ab prevents Scopolamine (HY-N0296) -induced memory impairment[1][2][3][4].

Product Specifications

CAS Number

[118194-13-1]

UNSPSC

12352005

Target

Apoptosis; PPAR; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/soyasaponin-ab.html

Purity

99.20

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]12[C@]3(C([C@@]4([H])[C@](C)([C@@H]([C@H](O)C(C)(C)C4)O[C@@]5([H])[C@@H]([C@H]([C@@H](O)CO5)O[C@@]6([H])[C@@H]([C@H]([C@H](OC(C)=O)[C@@H](COC(C)=O)O6)OC(C)=O)OC(C)=O)O)CC3)=CC[C@]1([H])[C@@]7([C@@]([C@](C)([C@@H](O[C@@]8([H])[C@@H]([C@H]([C@H](O)[C@@H](C(O)=O)O8)O)O[C@@]9([H])[C@@H]([C@H]([C@@H](O)[C@@H](CO)O9)O)O[C@]%10([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]%10O)CO)CC7)CO)([H])CC2)C)C

Molecular Formula

C67H104O33

Molecular Weight

1437.52

References & Citations

[1]Yang SH, et al. Soyasaponins Aa and Ab exert an anti-obesity effect in 3T3-L1 adipocytes through downregulation of PPARγ. Phytother Res. 2015 Feb;29 (2) :281-7.|[2]Liu X, et al. Soyasaponin Ab protects against oxidative stress in HepG2 cells via Nrf2/HO-1/NQO1 signaling pathways. Journal of Functional Foods. Volume 45, June 2018, Pages 110-117. |[3]Lee IA, et al. Soyasaponin Ab ameliorates colitis by inhibiting the binding of lipopolysaccharide (LPS) to Toll-like receptor (TLR) 4 on macrophages. J Agric Food Chem. 2011 Dec 28;59 (24) :13165-72.|[4]Hong SW, et al. Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase. J Agric Food Chem. 2014 Mar 5;62 (9) :2062-8.