CYP4A11/CYP4F2-IN-1
CYP4A11/CYP4F2-IN-1 is a potent dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 19 nM and 17 nM, respectively. CYP4A11/CYP4F2-IN-1 has potential for the research of renal diseases[1].
Product Specifications
CAS Number
[502654-40-2]
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cyp4a11-cyp4f2-in-1.html
Purity
99.82
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=C(SC=N1)CCOC2=CC=C(C=C2)C3=CC=NN3
Molecular Formula
C15H15N3OS
Molecular Weight
285.36
References & Citations
[1]Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65 (21) :14599-14613.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP4
Available Sizes
Curated Selection
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