Wnt-C59

Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.

Product Specifications

CAS Number

[1243243-89-1]

Product Name Alternative

C59

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Porcupine; Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Wnt-C59.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C2=CC=CN=C2)C=C1)CC3=CC=C(C4=CC(C)=NC=C4)C=C3

Molecular Formula

C25H21N3O

Molecular Weight

379.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Proffitt KD, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73 (2) :502-7.|[2]Cheng Y, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015 Jun 10;6 (16) :14428-39.