10058-F4

10058-F4 is a c-Myc inhibitor that prevents c-Myc-Max dimerization and transactivation of c-Myc target gene expression.

Product Specifications

CAS Number

[403811-55-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; c-Myc

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/10058-F4.html

Purity

99.90

Solubility

DMSO : ≥ 41 mg/mL

Smiles

O=C1NC(S/C1=C/C2=CC=C(CC)C=C2)=S

Molecular Formula

C12H11NOS2

Molecular Weight

249.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Huang MJ, et al. A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp Hematol. 2006 Nov;34 (11) :1480-9.|[2]Lin CP, et al. Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. Anticancer Drugs. 2007 Feb;18 (2) :161-70.|[3]Guo J, et al. Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z, E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother Pharmacol. 2009 Mar;63 (4) :615-25