Phthalazine

Phthalazine is a substrate for human aldehyde oxidase 1, which can lead to the production of ROS and subsequent enzyme inactivation. Phthalazine is a nitrogen-containing organic heterocyclic compound. Phthalazine exhibits antitumor activity in blood cancer, breast cancer, colon cancer, lung cancer and renal cancer[1][2].

Product Specifications

CAS Number

253-52-1

UNSPSC

12352005

Hazard Statement

H341, H412

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/phthalazine.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C12=CC=CC=C1C=NN=C2

Molecular Formula

C8H6N2

Molecular Weight

130.15

Precautions

H341, H412

References & Citations

[1]Garrido C, et al., The Inactivation of Human Aldehyde Oxidase 1 by Hydrogen Peroxide and Superoxide. Drug Metab Dispos. 2021 Sep;49 (9) :729-735. |[2]Sangshetti, J., et al., (2019) . Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review. Bioorganic & medicinal chemistry, 27 (18), 3979–3997.