Xylitol

Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model[1][2][3][4].

Product Specifications

CAS Number

[87-99-0]

Product Name Alternative

Xylite

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Atg7; Atg8/LC3; Autophagy; Bacterial; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/xylitol.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 110 mg/mL (ultrasonic)

Smiles

OC[C@@H](O)[C@H](O)[C@@H](O)CO

Molecular Formula

C5H12O5

Molecular Weight

152.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Cannon M, et al. Effects of Xylitol on Tumor Progression in Syngeneic Mice Cancer Models[J]. Nutraceuticals, 2025, 5 (1) : 4.|[2]Uebanso T, et al. Effects of consuming xylitol on gut microbiota and lipid metabolism in mice[J]. Nutrients, 2017, 9 (7) : 756.|[3]Park E, et al. Xylitol induces cell death in lung cancer A549 cells by autophagy. Biotechnol Lett. 2015 May;37 (5) :983-90.|[4]Uittamo J, et al. Xylitol inhibits carcinogenic acetaldehyde production by Candida species. Int J Cancer. 2011 Oct 15;129 (8) :2038-41.