Umeclidinium (bromide)

Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

Product Specifications

CAS Number

[869113-09-7]

Product Name Alternative

GSK573719A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Umeclidinium-bromide.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : ≥ 25 mg/mL

Smiles

OC(C12CC[N+](CC2)(CCOCC3=CC=CC=C3)CC1)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]

Molecular Formula

C29H34BrNO2

Molecular Weight

508.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Salmon M, et al. Pharmacological characterization of GSK573719 (umeclidinium) : a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013 May;345 (2) :260-70.|[2]Cazzola M, et al. Pharmacology and therapeutics of bronchodilators. Pharmacol Rev. 2012 Jul;64 (3) :450-504.|[3]Calzetta L, et al. Pharmacological characterization of the interaction between umeclidinium and vilanterol in human bronchi. Eur J Pharmacol. 2017 Jul 14. pii: S0014-2999 (17) 30470-3.