Fmoc-His (Trt) -OH
Fmoc-His (Trt) -OH is a histidine derivative. Fmoc-His (Trt) -OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His (Trt) -OH has Fmoc group to protect -αNH2. Fmoc-His (Trt) -OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1][2][3].
Product Specifications
CAS Number
109425-51-6
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Amino Acid Derivatives
Type
Peptides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/fmoc-his-trt-oh.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)CC4=CN(C=N4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)O
Molecular Formula
C40H33N3O4
Molecular Weight
619.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Yi Y, et, al. Suppression of Simultaneous Fmoc-His (Trt) -OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.|[2]Aggarwal S, et al. [DLys (6) ]-luteinizing hormone releasing hormone-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo. Int J Cancer. 2011 Oct 1;129 (7) :1611-23. |[3]Kamysz E, et al. Characterization of the effects of opiorphin and sialorphin and their analogs substituted in position 1 with pyroglutamic acid on motility in the mouse ileum. J Pept Sci. 2013 Mar;19 (3) :166-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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