Fmoc-His (Trt) -OH

Fmoc-His (Trt) -OH is a histidine derivative. Fmoc-His (Trt) -OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His (Trt) -OH has Fmoc group to protect -αNH2. Fmoc-His (Trt) -OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1][2][3].

Product Specifications

CAS Number

[109425-51-6]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives

Type

Peptides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fmoc-his-trt-oh.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)CC4=CN(C=N4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)O

Molecular Formula

C40H33N3O4

Molecular Weight

619.71

Precautions

H302, H315, H319, H335

References & Citations

[1]Yi Y, et, al. Suppression of Simultaneous Fmoc-His (Trt) -OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.|[2]Aggarwal S, et al. [DLys (6) ]-luteinizing hormone releasing hormone-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo. Int J Cancer. 2011 Oct 1;129 (7) :1611-23. |[3]Kamysz E, et al. Characterization of the effects of opiorphin and sialorphin and their analogs substituted in position 1 with pyroglutamic acid on motility in the mouse ileum. J Pept Sci. 2013 Mar;19 (3) :166-72.