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1-Cinnamoylpyrrolidine

1-Cinnamoylpyrrolidine (Compound 3), a crude extract prepared from Piper caninum, is a DNA strand scission agent, induces the relaxation of supercoiled pBR322 plasmid DNA[1]. 1-Cinnamoylpyrrolidine (Compound 4) inhibits platelet aggregation induced by PAF with an IC50 of 37.3 μM[2].

Product Specifications

CAS Number

52438-21-8

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

DNA/RNA Synthesis; Platelet-activating Factor Receptor (PAFR)

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/1-cinnamoylpyrrolidine.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCCC1)/C=C/C2=CC=CC=C2

Molecular Formula

C13H15NO

Molecular Weight

201.26

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Send toBioorg Med Chem.Ma J, et al. Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum. Bioorg Med Chem. 2004 Jul 15;12 (14) :3885-9.|[2]Chen IS, et al. Amides with anti-platelet aggregation activity from Piper taiwanense. Fitoterapia. 2007 Sep;78 (6) :414-9. Epub 2007 May 24.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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