BRD0639
BRD0639 is a first-in-class inhibitor of the PRMT5-substrate adaptor interaction. BRD0639 is a PRMT5 binding motif (PBM) -competitive agent that can support studies of PBM dependent PRMT5 activities[1].
Product Specifications
CAS Number
[2760881-74-9]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd0639.html
Purity
98.04
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C[C@H](N1C(C=C(Cl)C=N1)=O)C(NC2=CC=C(C)C(S(=O)(NCCC3=NC=CC=C3)=O)=C2)=O
Molecular Formula
C21H22ClN5O4S
Molecular Weight
475.95
References & Citations
[1]McKinney DC, et al. Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J Med Chem. 2021;64 (15) :11148-11168.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5
Available Sizes
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