Doravirine-13C, d3
Doravirine-13C, d3 (MK-1439-13C, d3) is the deuterium labeled Doravirine. Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively[1].
Product Specifications
Product Name Alternative
MK-1439-13C, d3
UNSPSC
12352005
Target
HIV; Isotope-Labeled Compounds; Reverse Transcriptase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
N#CC1=CC(OC2=C(C(F)(F)F)C=CN(CC(N3[13C]([2H])([2H])[2H])=NNC3=O)C2=O)=CC(Cl)=C1
Molecular Formula
C16 13CH8D3ClF3N5O3
Molecular Weight
429.76
References & Citations
[1]Lai MT et al. In vitro characterization of MK-1439, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2014;58 (3) :1652-63.|[2]Anderson MS et al. Safety, tolerability and pharmacokinetics of doravirine, a novel HIV non-nucleoside reverse transcriptase inhibitor, after single and multiple doses in healthy subjects. Antivir Ther. 2015;20 (4) :397-405.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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