Chinifur
Chinifur (Quinifuryl), a Nitrofuran derivative, is a selective inhibitor of trypanothione reductase and also a radical-generating substrate for trypanothione reductase (Ki = 4.5 μM) [1][2].
Product Specifications
CAS Number
70762-66-2
Product Name Alternative
Quinifuryl
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/chinifur.html
Purity
98.02
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC=CC2=NC(/C=C/C3=CC=C([N+]([O-])=O)O3)=C1)NC(CCCN(CC)CC)C
Molecular Formula
C25H30N4O4
Molecular Weight
450.53
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Iribarne F, et al. Interaction energies of nitrofurans with trypanothione reductase and glutathione reductase studied by molecular docking[J]. Journal of Molecular Structure: THEOCHEM, 2007, 818 (1-3) : 7-22.|[2]Cenas N, et al. Chinifur, a selective inhibitor and" subversive substrate" for Trypanosoma congolense trypanothione reductase[J]. Biochemical and biophysical research communications, 1994, 204 (1) : 224-229.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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