Chinifur

Chinifur (Quinifuryl), a Nitrofuran derivative, is a selective inhibitor of trypanothione reductase and also a radical-generating substrate for trypanothione reductase (Ki = 4.5 μM) [1][2].

Product Specifications

CAS Number

[70762-66-2]

Product Name Alternative

Quinifuryl

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/chinifur.html

Purity

98.02

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=CC=CC2=NC(/C=C/C3=CC=C([N+]([O-])=O)O3)=C1)NC(CCCN(CC)CC)C

Molecular Formula

C25H30N4O4

Molecular Weight

450.53

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Iribarne F, et al. Interaction energies of nitrofurans with trypanothione reductase and glutathione reductase studied by molecular docking[J]. Journal of Molecular Structure: THEOCHEM, 2007, 818 (1-3) : 7-22.|[2]Cenas N, et al. Chinifur, a selective inhibitor and" subversive substrate" for Trypanosoma congolense trypanothione reductase[J]. Biochemical and biophysical research communications, 1994, 204 (1) : 224-229.