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Ciforadenant

Ciforadenant (CPI-444) is a potent, orally active and selective adenosine A2A receptor (A2AR) antagonist, which induces antitumor responses[1].

Product Specifications

CAS Number

[1202402-40-1]

Product Name Alternative

CPI-444; V81444

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ciforadenant.html

Purity

99.85

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

NC1=NC(C2=CC=C(C)O2)=C(N=NN3CC4=NC(CO[C@@H]5COCC5)=CC=C4)C3=N1

Molecular Formula

C20H21N7O3

Molecular Weight

407.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Stephen Willingham, et al. Abstract PR04: CPI-444: A potent and selective inhibitor of A2AR induces antitumor responses alone and in combination with anti-PD-L1 in preclinical and clinical studies.Cancer Immunoly Research. September 25-28, 2016.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101978/Ciforadenant-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101978/Ciforadenant-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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