ERα degrader 8

ERα degrader 8 (Compound 18j) is a selective Estrogen Receptor degrader. ERα degrader 8 is degrader to MCF-7 cells with IC50 value of 0.15 μM[1].

Product Specifications

CAS Number

[2971837-95-1]

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/erα-degrader-8.html

Solubility

10 mM in DMSO

Smiles

OC(/C=C/C(C=C1)=CC=C1OC2=C(C(C3=CC=CC=C3CC)=O)C=NC4=CC(O)=CC=C42)=O

Molecular Formula

C27H21NO5

Molecular Weight

439.46

References & Citations

[1]Lu Y, et al. Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects. European Journal of Medicinal Chemistry, 2024: 116534.