ERα degrader 8
ERα degrader 8 (Compound 18j) is a selective Estrogen Receptor degrader. ERα degrader 8 is degrader to MCF-7 cells with IC50 value of 0.15 μM[1].
Product Specifications
CAS Number
2971837-95-1
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erα-degrader-8.html
Solubility
10 mM in DMSO
Smiles
OC(/C=C/C(C=C1)=CC=C1OC2=C(C(C3=CC=CC=C3CC)=O)C=NC4=CC(O)=CC=C42)=O
Molecular Formula
C27H21NO5
Molecular Weight
439.46
References & Citations
[1]Lu Y, et al. Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects. European Journal of Medicinal Chemistry, 2024: 116534.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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