Tibenelast (free acid)
Tibenelast (LY186655) free acid is a potent and orally active is a phosphodiesterase inhibitor. Tibenelast free acid is an anti-asthma agent Tibenelast free acid increases the heart rate response to isoproterenol. Tibenelast free acid shows anti-anaphylactic shock activity. Tibenelast free acid has the potential for the research of asthma and other respiratory diseases[1][2].
Product Specifications
CAS Number
97852-72-7
Product Name Alternative
LY186655 (free acid)
UNSPSC
12352211
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tibenelast-free-acid.html
Smiles
O=C(C1=CC2=C(C=C(C(OCC)=C2)OCC)S1)O
Molecular Formula
C13H14O4S
Molecular Weight
266.31
References & Citations
[1]Ho PP, et al. Tibenelast, 5,6-diethoxybenzo (B) thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46 (13) :917-25. |[2]Schwertschlag US, et al. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46 (3) :142-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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