Ethyl ferulate

Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42) -induced oxidative stress and neurotoxicity[2].

Product Specifications

CAS Number

[4046-02-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Ethyl_ferulate.html

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(OCC)/C=C/C1=CC=C(O)C(OC)=C1

Molecular Formula

C12H14O4

Molecular Weight

222.24

Precautions

H315, H319, H335

References & Citations

[1]Scapagnini G, et al. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004 Oct;6 (5) :811-8.|[2]Sultana R, et al. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide (1-42) -induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem. 2005 Feb;92 (4) :749-58.|[3]Wang Y, et al. Ethyl ferulate contributes to the inhibition of the inflammatory responses in murine RAW 264.7 macrophage cells and acute lung injury in mice. PLoS One. 2021 May 26;16 (5) :e0251578. |[4]Wu YX, et al. Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway. Acta Pharmacol Sin. 2021 Dec;42 (12) :2069-2081. |[5]Xue R, et al. Protective effect of ethyl ferulate against hypoxic injury in retinal cells and retinal neovascularization in an oxygen-induced retinopathy model. Phytomedicine. 2023 Dec;121:155097.