Copper Fluor-4

Copper Fluor-4 (CF4) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9x10−13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission) [1][2][3].

Product Specifications

CAS Number

[2365532-64-3]

Product Name Alternative

CF4

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/copper-fluor-4.html

Purity

98.44

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=C(C3=C(C(F)(F)F)C=C(CN(CCSCCSCC)CCSCCSCC)C=C3)C4=C(C=C(N5CCCCC5)C=C4)OC2=C1

Molecular Formula

C38H47F3N2O2S4

Molecular Weight

749.05

References & Citations

[1]Xiao T, et al. Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Nat Chem Biol. 2018 Jul;14 (7) :655-663.|[2]Weishaupt AK, et al. Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis in C. elegans. Front Mol Biosci. 2024 Feb 8;11:1354627. |[3]Chakraborty K, et al. Copper dependent ERK1/2 phosphorylation is essential for the viability of neurons and not glia. Metallomics. 2022 Apr 1;14 (4) :mfac005.