ML-00253764 (hydrochloride)
Product Specifications
UNSPSC Description
ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively[1].
Target Antigen
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ml-00253764-hydrochloride.html
Purity
99.47
Solubility
DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
FC1=C(CCC2=CC(Br)=CC=C2OC)C(C3=NCCN3)=CC=C1.[H]Cl
Molecular Weight
413.71
References & Citations
[1]Vos TJ, et al. Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J Med Chem. 2004 Mar 25;47(7):1602-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-110123/ML-00253764-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-110123/ML-00253764-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1706524-94-8
Available Sizes
Curated Selection
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