ML-00253764 (hydrochloride)
ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively[1].
Product Specifications
CAS Number
[1706524-94-8]
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ml-00253764-hydrochloride.html
Purity
99.29
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=C(CCC2=CC(Br)=CC=C2OC)C(C3=NCCN3)=CC=C1.[H]Cl
Molecular Formula
C18H19BrClFN2O
Molecular Weight
413.71
References & Citations
[1]Vos TJ, et al. Identification of 2-[2-[2- (5-bromo-2- methoxyphenyl) -ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J Med Chem. 2004 Mar 25;47 (7) :1602-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MC4R
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
457760-01 1 mg
N-[4- (1, 1-Dimethylethyl) benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6, N6-diethyl-L-lysyl-L-serine Methyl Ester
Ask
View Details ![N-[4- (1, 1-Dimethylethyl) benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6, N6-diethyl-L-lysyl-L-serine Methyl Ester](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
457760-02 5 mg
N-[4- (1, 1-Dimethylethyl) benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6, N6-diethyl-L-lysyl-L-serine Methyl Ester
Ask
View Details 