ML-00253764 (hydrochloride)

ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively[1].

Product Specifications

CAS Number

[1706524-94-8]

UNSPSC

12352005

Target

Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/ml-00253764-hydrochloride.html

Purity

99.29

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=C(CCC2=CC(Br)=CC=C2OC)C(C3=NCCN3)=CC=C1.[H]Cl

Molecular Formula

C18H19BrClFN2O

Molecular Weight

413.71

References & Citations

[1]Vos TJ, et al. Identification of 2-[2-[2- (5-bromo-2- methoxyphenyl) -ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J Med Chem. 2004 Mar 25;47 (7) :1602-4.