BLT-1
BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor[1][2][3][4].
Product Specifications
CAS Number
321673-30-7
Product Name Alternative
Block lipid transport-1
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/blt-1.html
Purity
99.93
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
CCCCCCC1CCC/C1=N/NC(N)=S
Molecular Formula
C12H23N3S
Molecular Weight
241.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Raldúa D, et al. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol Lett. 2007 Dec 10;175 (1-3) :1-7. Epub 2007 Aug 22.|[2]Nieland TJ, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47 (1) :460-72.|[3]Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99 (24) :15422-7.|[4]Hirofumi Ohashi, et al. Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments. Proc Natl Acad Sci U S A. 2017 Jun 6;114 (23) :E4527-E4529.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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