BLT-1

BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor[1][2][3][4].

Product Specifications

CAS Number

[321673-30-7]

Product Name Alternative

Block lipid transport-1

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/blt-1.html

Purity

99.93

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

CCCCCCC1CCC/C1=N/NC(N)=S

Molecular Formula

C12H23N3S

Molecular Weight

241.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Raldúa D, et al. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol Lett. 2007 Dec 10;175 (1-3) :1-7. Epub 2007 Aug 22.|[2]Nieland TJ, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47 (1) :460-72.|[3]Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99 (24) :15422-7.|[4]Hirofumi Ohashi, et al. Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments. Proc Natl Acad Sci U S A. 2017 Jun 6;114 (23) :E4527-E4529.