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HIF-2α agonist 3

HIF-2α agonist 3 (Compound 14d) is an orally active HIF-2α agonist with a EC50 value of 1.78 μM. HIF-2α agonist 3 can be used in the study of renal anemia[1].

Product Specifications

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hif-2α-agonist-3.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=CC=C1C2=C(C(NC3=CC=CC(C(F)(F)F)=C3)=O)C=NN2

Molecular Formula

C17H11ClF3N3O

Molecular Weight

365.74

References & Citations

[1]Chen S, et al. Identification of 3-aryl-5-methyl-isoxazole-4-carboxamide derivatives and analogs as novel HIF-2α agonists through docking-based virtual screening and structural modification. Eur J Med Chem. 2024 Feb 16;268:116227.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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