HIF-2α agonist 3
HIF-2α agonist 3 (Compound 14d) is an orally active HIF-2α agonist with a EC50 value of 1.78 μM. HIF-2α agonist 3 can be used in the study of renal anemia[1].
Product Specifications
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hif-2α-agonist-3.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC=C1C2=C(C(NC3=CC=CC(C(F)(F)F)=C3)=O)C=NN2
Molecular Formula
C17H11ClF3N3O
Molecular Weight
365.74
References & Citations
[1]Chen S, et al. Identification of 3-aryl-5-methyl-isoxazole-4-carboxamide derivatives and analogs as novel HIF-2α agonists through docking-based virtual screening and structural modification. Eur J Med Chem. 2024 Feb 16;268:116227.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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