M-Iodobenzylguanidine (sulfate)

M-Iodobenzylguanidine sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated m-Iodobenzylguanidine sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. m-Iodobenzylguanidine sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono (ADP-ribosylation) [1][2].

Product Specifications

CAS Number

[87862-25-7]

Product Name Alternative

MIBG (sulfate) ; Iobenguane (sulfate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/iobenguane-sulfate.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC(NCC1=CC=CC(I)=C1)=N.O=S(O)(O)=O.[1/2]

Molecular Formula

C8H10IN3.1/2H2O4S

Molecular Weight

324.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Loesberg C, et al. Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono (ADP-ribosylation) . Biochim Biophys Acta. 1990 Jan 19;1037 (1) :92-9.