Deferitrin

Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2].

Product Specifications

CAS Number

[239101-33-8]

Product Name Alternative

GT-56-252

UNSPSC

12352005

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/deferitrin.html

Purity

99.32

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C([C@]1(C)N=C(C2=CC=C(O)C=C2O)SC1)O

Molecular Formula

C11H11NO4S

Molecular Weight

253.27

References & Citations

[1]Raymond J Bergeron, et al. Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether Analogues. J Med Chem. 2008 Jul 10;51 (13) :3913-23.|[2]Joanne M Donovan, et al. Preclinical and Clinical Development of Deferitrin, a Novel, Orally Available Iron Chelator. Ann N Y Acad Sci. 2005;1054:492-4.