L-2-Hydroxyglutaric acid (Standard)
L-2-Hydroxyglutaric acid (Standard) is the analytical standard of L-2-Hydroxyglutaric acid. This product is intended for research and analytical applications. L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].
Product Specifications
CAS Number
[13095-48-2]
Product Name Alternative
(S) -2-Hydroxyglutaric acid (Standard)
UNSPSC
12352211
Target
Endogenous Metabolite; Histone Demethylase; Mitochondrial Metabolism; Reference Standards
Type
Reference Standards
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-2-hydroxyglutaric-acid-standard.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@@H](O)CCC(O)=O
Molecular Formula
C5H8O5
Molecular Weight
148.11
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported
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