(±) -Catechin

(±) -Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±) -Catechin has two forms, (+) -Catechin and its enantiomer (-) -Catechin. (+) -Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-) -Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±) -Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects[1][2][3].

Product Specifications

CAS Number

[7295-85-4]

Product Name Alternative

Rel-Cianidanol; rel-Catechuic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/racemic-catechin.html

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@H](OC2=CC(O)=CC(O)=C2C1)C3=CC=C(C(O)=C3)O

Molecular Formula

C15H14O6

Molecular Weight

290.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Mamoru Isemura. Catechin in Human Health and Disease. Molecules. 2019 Feb 1;24 (3) :528.|[2]Shin DW, et al. (-) -Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPAR gamma transactivation. Biochem Pharmacol. 2009 Jan 1;77 (1) :125-33.|[3]Nakazato T, et al. Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Clin Cancer Res. 2005 Aug 15;11 (16) :6040-9.