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Anantin

Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 μM) and acts as natriuretic peptide receptor A antagonist[1][2].

Product Specifications

CAS Number

133658-45-4

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/anantin.html

Solubility

10 mM in DMSO

Smiles

O=C(CNC([C@](NC([C@@H](NC(CNC(C[C@H](NC([C@@H](NC(CNC1=O)=O)CC(N)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)CC4=CN=CN4)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)CC6=CC=CC=C6)=O)([H])[C@@H](C)CC)=O)N[C@H]1CC7=CNC8=CC=CC=C78

Molecular Formula

C90H111N21O24

Molecular Weight

1870.97

References & Citations

[1]Wyss DF, et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF) . II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo) . 1991 Feb;44 (2) :172-80.https://pubmed.ncbi.nlm.nih.gov/1826288/1. Wyss DF, et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF) . II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo) . 1991 Feb;44 (2) :172-80.|[2]Nachshon S, et al. Effects of ANP receptor antagonists on ANP secretion from adult rat cultured atrial myocytes. Am J Physiol. 1995 Mar;268 (3 Pt 1) :E428-32.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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