YDR1

YDR1 is a potent PROTAC SMARCA2 degrader, with the DC50 of 7.7 nM. YDR1 plays an important role in SMARCA4 mutant cancers (Sturcture Note: (Blue: Cereblon ligand (HY-W087383), Black: linker; Pink: SMARCA2 ligand (HY-44012B) ) [1].

Product Specifications

CAS Number

[2951015-31-7]

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ydr1.html

Purity

98.03

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC(N4CCN(CC5CCN(C6=C(F)C=C(CN7CCN(C8=C(N)N=NC(C9=C(O)C=CC=C9)=C8)CC7)C=C6)CC5)CC4)=C3

Molecular Formula

C44H49FN10O5

Molecular Weight

816.92

References & Citations

[1]Sasikumar Kotagiri, et al. Discovery of Novel, Potent and Orally Bioavailable SMARCA2 PROTACs with Synergistic Anti-tumor Activity in Combination with KRAS G12C Inhibitors. bioRxiv [Preprint]. 2024 Aug 26:2024.08.23.608456.