EGFR-IN-117
EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutation, targets the tumor environment, and induces apoptosis of cancer cells. EGFR-IN-117 inhibits proliferations of H1975, PC-9, and EGFR mutant cells BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 of 13 nM, 19 nM, 1.2 nM and 1.3 nM, respectively. EGFR-IN-117 exhibits antitumor efficacy in mouse models[1].
Product Specifications
CAS Number
3035639-05-2
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-117.html
Smiles
O=S(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCCN(C)CC4)C=C3)=NC=C2Br)(C5CC5)=O
Molecular Formula
C25H30BrN7O2S
Molecular Weight
572.52
References & Citations
[1]Yao H, et al., Discovery of new cyclopropane sulfonamide derivatives as EGFR inhibitors to overcome C797S-mediated resistance and EGFR double mutation. Eur J Med Chem. 2024 Jun 16;275:116590.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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