Human DENR Protein

<strong>Human DENR Protein</strong>_x000D_ <strong>Catalog number:</strong> B2012148_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 0.5 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> SMAP-3 protein, DRP protein, Density-regulated protein, DRP1 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA. Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1 Cell Rep. 2017 Jul 18;20(3):521-528._x000D_ 2: Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB. DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion Nat Commun. 2022 Apr 19;13(1):2059._x000D_ 3: Mazan-Mamczarz K, Gartenhaus RB. Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1 Cancer Genomics Proteomics. 2007 May-Jun;4(3):233-9._x000D_ 4: Lomakin IB, De S, Wang J, Borkar AN, Steitz TA. Crystal structure of the C-terminal domain of DENR Comput Struct Biotechnol J. 2020 Mar 19;18:696-704._x000D_ 5: Lomakin IB, Dmitriev SE, Steitz TA. Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):528-533._x000D_ 6: Clemm von Hohenberg K, Müller S, Schleich S, Meister M, Bohlen J, Hofmann TG, Teleman AA. Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division Nat Commun. 2022 Feb 3;13(1):668._x000D_ 7: Ahmed YL, Schleich S, Bohlen J, Mandel N, Simon B, Sinning I, Teleman AA. DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation PLoS Biol. 2018 Jun 11;16(6):e2005160._x000D_ 8: Schleich S, Acevedo JM, Clemm von Hohenberg K, Teleman AA. Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells Sci Rep. 2017 Jun 16;7(1):3722._x000D_ 9: Castelo-Szekely V, De Matos M, Tusup M, Pascolo S, Ule J, Gatfield D. Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock Nucleic Acids Res. 2019 Jun 4;47(10):5193-5209._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/32938922">10: Bohlen J, Harbrecht L, Blanco S, Clemm von Hohenberg K, Fenzl K, Kramer G, Bukau B, Teleman AA. DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4 Nat Commun. 2020 Sep 16;11(1):4676. </a>_x000D_ _x000D_ <strong>Products Related to Human DENR Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>