Xylopine

Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells[1].

Product Specifications

CAS Number

[517-71-5]

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xylopine.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC1=CC=C2C3=C4C(CCN[C@]4([H])CC2=C1)=CC5=C3OCO5

Molecular Formula

C18H17NO3

Molecular Weight

295.33

References & Citations

[1]Luciano de Souza Santos, et al. Xylopine Induces Oxidative Stress and Causes G 2/M Phase Arrest, Triggering Caspase-Mediated Apoptosis by p53-Independent Pathway in HCT116 Cells. Oxid Med Cell Longev. 2017;2017:7126872.