CHI3L1-IN-2

CHI3L1-IN-2 (Compound 36) is a CHI3L1 (Chitinase-3-Like Protein 1) inhibitor. CHI3L1-IN-2 inhibits the interaction between CHI3L1 and heparan sulfate (CHI3L1:HSIII), with an IC50 of 26 nM. CHI3L1, also known as YKL-40, is a glycoprotein associated with inflammation, fibrosis, and cancer[1].

Product Specifications

CAS Number

[2982257-63-4]

UNSPSC

12352005

Target

Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/chi3l1-in-2.html

Purity

98.19

Solubility

10 mM in DMSO

Smiles

CC(C)C[C@H](N(C1)C)CN(C2CCN(C3=CC=CC=N3)CC2)[C@H]1CC4=CC=C(C=C4)Cl

Molecular Formula

C26H37ClN4

Molecular Weight

441.05

References & Citations

[1]Czestkowski W, et al. Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1. J Med Chem. 2024 Mar 14;67 (5) :3959-3985.