Recombinant Human IL-32α Protein (Trx Tag)

IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, Mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis, and in the human stomach cancer, human lung cancer, and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

TAIFa; IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; TAIFb; TAIFc; TAIFd; IL32; NK4; TAIF; IL 32alpha; IL 32beta; IL 32delta; IL 32gamma; IL-32; Interleukin 32; Interleukin 32 small; Interleukin 32 theta; Interleukin-32; interleukin-32 eta; Natural killer cell transcript 4; Natural killer cells protein 4; NK 4; OTTHUMP00000236040; OTTHUMP00000236041; OTTHUMP00000236042; OTTHUMP00000236043; OTTHUMP00000236044; OTTHUMP00000236045; OTTHUMP00000236046; OTTHUMP00000236047; OTTHUMP00000236048; OTTHUMP00000236049; OTTHUMP00000236050; OTTHUMP00000236051; OTTHUMP00000236052; OTTHUMP00000236053; OTTHUMP00000236054; OTTHUMP00000241545; OTTHUMP00000241602; OTTHUMP00000241603; OTTHUMP00000241604; OTTHUMP00000241605; OTTHUMP00000241606; OTTHUMP00000241607; OTTHUMP00000241608; OTTHUMP00000241609; OTTHUMP00000241610; OTTHUMP00000241611; OTTHUMP00000241612; Tumor necrosis factor alpha-inducing factor

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.