6-T-GDP

6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation[1].

Product Specifications

CAS Number

[16541-19-8]

Product Name Alternative

6-Thioguanosine 5'-diphosphate

UNSPSC

12352005

Target

Endogenous Metabolite; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/6-t-gdp.html

Smiles

O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O[C@H]1N(C=N2)C3=C2C(NC(N)=N3)=S

Molecular Formula

C10H15N5O10P2S

Molecular Weight

459.27

References & Citations

[1]Marinković, et al. Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug. The Journal of Immunology 192.9 (2014) : 4370-4378.