6-T-GDP
Product Specifications
UNSPSC Description
6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation[1].
Target Antigen
Endogenous Metabolite; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway;Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/6-t-gdp.html
Smiles
O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O[C@H]1N(C=N2)C3=C2C(NC(N)=N3)=S
Molecular Weight
459.27
References & Citations
[1]Marinković, et al. Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug. The Journal of Immunology 192.9 (2014): 4370-4378.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134243/6-T-GDP-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134243/
Clinical Information
No Development Reported
CAS Number
16541-19-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
