N-Arachidonoylserotonin
N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM) . N-Arachidonoylserotonin is analgesic in rodents [1].
Product Specifications
CAS Number
[187947-37-1]
Product Name Alternative
Arachidonyl serotonin; AA-5-HT
UNSPSC
12352005
Hazard Statement
H225, H319, H336
Target
FAAH; TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/n-arachidonoylserotonin.html
Concentration
108.07 mM * 1 mL in Methyl acetate
Purity
99.11
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCC1=CNC2=C1C=C(O)C=C2)=O
Molecular Formula
C30H42N2O2
Molecular Weight
462.67
Precautions
H225, H319, H336
References & Citations
[1]Ortar G, et al. New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. J Med Chem. 2007;50 (26) :6554-6569.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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