TFEB activator 3
TFEB activator 3 (compound 45) exhibits TFEB activation and lysosome biogenesis capabilities. TFEB activator 3 has effect on TFEB nuclear translocation with 44% (10μM 3h) and 97 % (30 μM 3h) . TFEB activator 3 plays an important role in Alzheimer’s disease (AD) . TFEB activator 3 can pass blodd brain barrier[1].
Product Specifications
CAS Number
3027413-48-2
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tfeb-activator-3.html
Smiles
C12=C(C(NCC2)CCC3=CNC4=C3C=CC=C4)C=C5C(OCO5)=C1
Molecular Formula
C20H20N2O2
Molecular Weight
320.39
References & Citations
[1]Jianhui Zhou, et al. Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease. J Med Chem. 2024 Jun 13;67 (11) :8836-8861.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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