N-Nitrosodiethylamine-d4
N-Nitrosodiethylamine-d4 is the deuterium labeled N-Nitrosodiethylamine[1]. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
Product Specifications
CAS Number
[1346603-41-5]
Product Name Alternative
Diethylnitrosamine-d4; DEN-d4; DENA-d4
UNSPSC
12352211
Hazard Statement
H301, H341, H350, H412
Target
DNA/RNA Synthesis
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
CC([2H])([2H])N(N=O)C([2H])([2H])C
Molecular Formula
C4H6D4N2O
Molecular Weight
106.16
Precautions
H301, H341, H350, H412
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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