Fazirsiran (sodium)
Product Specifications
Product Name Alternative
ARO-AAT (sodium)
UNSPSC Description
Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes[1]. Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease.
Target Antigen
Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Epigenetics
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fazirsiran-sodium.html
Purity
93.86
Solubility
10 mM in H2O
Smiles
[Fazirsiran (sodium)]
Molecular Weight
16532.90
References & Citations
[1]Christine I Wooddell, et al. Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease. JCI Insight. 2020 Jun 18;5(12):e135348.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132604A/Fazirsiran-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132604A/Fazirsiran-sodium-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
2175009-09-1
Available Sizes
Curated Selection
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