HLE-IN-1

HLE-IN-1 (Compound 4) is a human leukocyte elastase HLE inhibitor (Ki=1.8 nM) . HLE-IN-1 is used in emphysema and inflammamry pulmonary research[1].

Product Specifications

CAS Number

[13947-21-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hle-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2C=CC=C1)N(CCl)S2(=O)=O

Molecular Formula

C8H6ClNO3S

Molecular Weight

231.66

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Hlasta, et al. A benzisothiazolone class of potent, selective mechanism-based inhibitors of human leukocyte elastase. Bioorganic & Medicinal Chemistry Letters, 4 (15), 1801–1806.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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