Anti-Cav3.1 Ca+2 Channel Antibody

Mouse Monoclonal Antibody specific to Cav3.1 Ca+2 Channel

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-Cav3.1 Ca+2 Channel Mouse Monoclonal Antibody

Gene Name

Cacna1g

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=Cacna1g">Cacna1g</a>

UniProt

Q9WUT2

Accession Number

NP_001106284.1

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Fusion protein corresponding to aa 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1 (accession no. NP_001106284.1).

Target Antigen

Voltage-dependent T-type calcium channel subunit α

Target

Cav3.1 Ca+2 Channel

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, IHC, ICC/IF

Field of Research

Ion Channels

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Additionnal Information

Immunoblotting: use at 1-2ug/mL. A band of >200kDa is detected. Immunohistochemistry: use at 1-10ug/mL. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain membranes.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Specificity

This antibody recognizes human, mouse, and rat Cav3.1. It does not cross-react with Cav3.2.

Formulation

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

Buffer pH

pH 7.4

Target Background

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Cav3.1 is a low-voltage- activated T-type calcium channel expressed throughout the body. Drugs that block T-type calcium channels are used as antihypertensives and antiepileptics and possibly in some anesthetics and antipsychotics.