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Afoxolaner (Standard)

Afoxolaner (Standard) is the analytical standard of Afoxolaner. This product is intended for research and analytical applications. Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].

Product Specifications

CAS Number

1093861-60-9

UNSPSC

12352005

Target

Chloride Channel; GABA Receptor; Parasite; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/afoxolaner-standard.html

Smiles

O=C(C1=C2C=CC=CC2=C(C3=NOC(C(F)(F)F)(C4=CC(C(F)(F)F)=CC(Cl)=C4)C3)C=C1)NCC(NCC(F)(F)F)=O

Molecular Formula

C26H17ClF9N3O3

Molecular Weight

625.87

References & Citations

[1]Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201 (3-4) :223-5.|[2]Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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