TERT activator-1
TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT) . TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging[1].
Product Specifications
CAS Number
[666699-46-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AP-1; ERK; MEK
Type
Reference compound
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tert-activator-1.html
Purity
99.50
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(NC1=CC=C(C(Cl)=C1)F)(C2=CC(C)=C(F)C(C)=C2)=O
Molecular Formula
C14H12ClF2NO2S
Molecular Weight
331.77
Precautions
H302, H315, H319, H335
References & Citations
[1]Shim HS, et al. TERT activation targets DNA methylation and multiple aging hallmarks. Cell. 2024 Jul 25;187 (15) :4030-4042.e13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2; MEK1; MEK2
Available Sizes
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