TIM-3-IN-2
Product Specifications
UNSPSC Description
TIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (KD: 0.61 μM). TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines[1].
Target Antigen
Tim3
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tim-3-in-2.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(C=C(C=C1)OC)OC)COC2=CC=CC(C3=NC(C4=CC=C(C=C4)OC)=NO3)=C2
Molecular Weight
461.47
References & Citations
[1]Abdel-Rahman SA, et al. Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual Screening. J Med Chem. 2023 Aug 24;66(16):11464-11475.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155175/TIM-3-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155175/TIM-3-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1113126-49-0
Available Sizes
Curated Selection
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