Carfilzomib-d8
Product Specifications
UNSPSC Description
Carfilzomib-d8 is deuterium labeled Carfilzomib. Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.
Target Antigen
Apoptosis; Autophagy; Isotope-Labeled Compounds; Proteasome
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis;Autophagy;Metabolic Enzyme/Protease;Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.93
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@@H](NC(CN2C([2H])(C([2H])(OC([2H])(C2([2H])[2H])[2H])[2H])[2H])=O)CCC3=CC=CC=C3)=O)=O)=O)CC(C)C)[C@@]4(OC4)C
Molecular Weight
727.96
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Dasmahapatra G, et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Mol Cancer Ther. 2011 Sep;10(9):1686-97.|[3]Kuhn DJ, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood. 2007 Nov 1;110(9):3281-90.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Clinical Information
No Development Reported
CAS Number
1537187-53-3
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6174079-01 0.1 mL
SSH1 (slingshot Homolog 1 (Drosophila), FLJ38102, KIAA1298, SSH-1) (Biotin)
Ask
View Details 
MBS6174079-02 5x 0.1 mL
SSH1 (slingshot Homolog 1 (Drosophila), FLJ38102, KIAA1298, SSH-1) (Biotin)
Ask
View Details